Targeted resequencing of GWAS loci reveals novel genetic variants for milk production traits.

ABSTRACT:

Background

Genome wide association study (GWAS) has been proven to be a powerful tool for detecting genomic variants associated with complex traits. However, the specific genes and causal variants underlying these traits remain unclear.

Results

Here, we used target-enrichment strategy coupled with next generation sequencing technique to study target regions which were found to be associated with milk production traits in dairy cattle in our previous GWAS. Among the large amount of novel variants detected by targeted resequencing, we selected 200 SNPs for further association study in a population consisting of 2634 cows. Sixty six SNPs distributed in 53 genes were identified to be associated significantly with on milk production traits. Of the 53 genes, 26 were consistent wit

SUBMITTER: Jiang L 

PROVIDER: S-EPMC4377845 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature