Intrinsically disordered proteins (IDPs) in trypanosomatids.

ABSTRACT:

Background

Proteins are composed of one or more amino acid chains and exhibit several structure levels. IDPs (intrinsically disordered proteins) represent a class of proteins that do not fold into any particular conformation and exist as dynamic ensembles in their native state. Due to their intrinsic adaptability, IDPs participate in many regulatory biological processes, including parasite immune escape. Using the information from trypanosomatids proteomes, we developed a pipeline for the identification, characterization and analysis of IDPs. The pipeline employs six disorder prediction methodologies and integrates structural and functional annotation information, subcellular location prediction and physicochemical properties. At the core of the IDP pipeline, there is a relational

SUBMITTER: de Cassia Ruy P 

PROVIDER: S-EPMC4378006 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature