Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy.

ABSTRACT:

Background

Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction between genes whose protein products potentially influence each other, which limits its power to identify molecular wiring of tumour cells dictating response to a drug. Due to the fact that signal transduction pathways are not linear and highly interlinked, the biological response they drive may be better described by the relative amount of their components and their functional relationships than by their individual, absolute expression.

Results

Gene expression microarray data for 109 tumor cell lines with known sensitivity to the death ligand cytokine tumor

SUBMITTER: O'Reilly P 

PROVIDER: S-EPMC4378270 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature