Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2.

ABSTRACT:

Objective

Arginase 2 (Arg2) is a critical target in atherosclerosis because it controls endothelial nitric oxide, proliferation, fibrosis, and inflammation. Regulators of Arg2 transcription in the endothelium have not been characterized. The goal of the current study is to determine the role of specific histone deacetylases (HDACs) in the regulation of endothelial Arg2 transcription and endothelial function.

Approach and results

The HDAC inhibitor trichostatin A increased levels of Arg2 mRNA, protein, and activity in both human aortic endothelial cells and mouse aortic rings. These changes occurred in both time- and dose-dependent patterns and resulted in Arg2-dependent endothelial dysfunction. Trichostatin A and the atherogenic stimulus oxidized low-density lipoprotein enha

SUBMITTER: Pandey D 

PROVIDER: S-EPMC4378272 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature