The direct arylation of allylic sp(3) C-H bonds via organic and photoredox catalysis.

ABSTRACT: The direct functionalization of unactivated sp(3) C-H bonds is still one of the most challenging problems facing synthetic organic chemists. The appeal of such transformations derives from their capacity to facilitate the construction of complex organic molecules via the coupling of simple and otherwise inert building blocks, without introducing extraneous functional groups. Despite notable recent efforts, the establishment of general and mild strategies for the engagement of sp(3) C-H bonds in C-C bond forming reactions has proved difficult. Within this context, the discovery of chemical transformations that are able to directly functionalize allylic methyl, methylene and methine carbons in a catalytic manner is a priority. Although protocols for direct oxidation and amination of allylic

SUBMITTER: Cuthbertson JD 

PROVIDER: S-EPMC4378681 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature