Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.

ABSTRACT:

Importance

Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied.

Objective

To examine the effects of 6 weeks of escitalopram treatment vs placebo on MSIMI and other psychological stress-related biophysiological and emotional parameters.

Design, setting, and participants

The REMIT (Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment) study, a randomized, double-blind, placebo-controlled trial of patients with clinically stable coronary heart disease and laboratory-diagnosed MSIMI. Enrollment occurred from July 24, 2007, through August 24, 2011, at a tertiary

SUBMITTER: Jiang W 

PROVIDER: S-EPMC4378823 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature