Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

ABSTRACT: Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathway

SUBMITTER: Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium 

PROVIDER: S-EPMC4378867 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature