Identifying and tracking simulated synaptic inputs from neuronal firing: insights from in vitro experiments.

ABSTRACT: Accurately describing synaptic interactions between neurons and how interactions change over time are key challenges for systems neuroscience. Although intracellular electrophysiology is a powerful tool for studying synaptic integration and plasticity, it is limited by the small number of neurons that can be recorded simultaneously in vitro and by the technical difficulty of intracellular recording in vivo. One way around these difficulties may be to use large-scale extracellular recording of spike trains and apply statistical methods to model and infer functional connections between neurons. These techniques have the potential to reveal large-scale connectivity structure based on the spike timing alone. However, the interpretation of functional connectivity is often approximate, since onl

SUBMITTER: Volgushev M 

PROVIDER: S-EPMC4379067 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature