Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β.

ABSTRACT:

Scope

Extracellular vesicles, including exosomes, have been identified in all biological fluids and rediscovered as an important part of the intercellular communication. Breast milk also contains extracellular vesicles and the proposed biological function is to enhance the antimicrobial defense in newborns. It is, however, unknown whether extracellular vesicles are still present in commercial milk and, more importantly, whether they retained their bioactivity. Here, we characterize the extracellular vesicles present in semi-skimmed cow milk available for consumers and study their effect on T cells.

Methods and results

Extracellular vesicles from commercial milk were isolated and characterized. Milk-derived extracellular vesicles contained several immunomodulating miRNAs and

SUBMITTER: Pieters BC 

PROVIDER: S-EPMC4379073 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature