A polymorphism in HLA-G modifies statin benefit in asthma.
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ABSTRACT:
SUBMITTER: Naidoo D
PROVIDER: S-EPMC4379135 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
A polymorphism in HLA-G modifies statin benefit in asthma.
Naidoo D D Wu A C AC Brilliant M H MH Denny J J Ingram C C Kitchner T E TE Linneman J G JG McGeachie M J MJ Roden D M DM Shaffer C M CM Shah A A Weeke P P Weiss S T ST Xu H H Medina M W MW
The pharmacogenomics journal 20140930 3
Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3'UTR that is associated with asthma risk, modulates miRNA binding. We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion. In addition, we found that indiv ...[more]
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