Parallel functional changes in independent testis-specific duplicates of Aldehyde dehydrogenase in Drosophila.

ABSTRACT: A large proportion of duplicates, originating from ubiquitously expressed genes, acquire testis-biased expression. Identifying the underlying cause of this observation requires determining whether the duplicates have altered functions relative to the parental genes. Typically, statistical methods are used to test for positive selection, signature of which in protein sequence of duplicates implies functional divergence. When assumptions are violated, however, such tests can lead to false inference of positive selection. More convincing evidence for naturally selected functional changes would be the occurrence of structural changes with similar functional consequences in independent duplicates of the same gene. We investigated two testis-specific duplicates of the broadly expressed enzyme ge

SUBMITTER: Chakraborty M 

PROVIDER: S-EPMC4379408 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature