Uncovering RNA binding proteins associated with age and gender during liver maturation.

ABSTRACT: In the present study, we perform an association analysis focusing on the expression changes of 1344 RNA Binding proteins (RBPs) as a function of age and gender in human liver. We identify 88 and 45 RBPs to be significantly associated with age and gender respectively. Experimental verification of several of the predicted associations in mice confirmed our findings. Our results suggest that a small fraction of the gender-associated RBPs (~40%) are expressed higher in males than females. Altogether, these observations show that several of these RBPs are important and conserved regulators in maintaining liver function. Further analysis of the protein interaction network of RBPs associated with age and gender based on the centrality measures like degree, betweenness and closeness revealed that

SUBMITTER: Chaturvedi P 

PROVIDER: S-EPMC4379467 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature