Profiling of measles-specific humoral immunity in individuals following two doses of MMR vaccine using proteome microarrays.

ABSTRACT:

Introduction

Comprehensive evaluation of measles-specific humoral immunity after vaccination is important for determining new and/or additional correlates of vaccine immunogenicity and efficacy.

Methods

We used a novel proteome microarray technology and statistical modeling to identify factors and models associated with measles-specific functional protective immunity in 150 measles vaccine recipients representing the extremes of neutralizing antibody response after two vaccine doses.

Results

Our findings demonstrate a high seroprevalence of antibodies directed to the measles virus (MV) phosphoprotein (P), nucleoprotein (N), as well as antibodies to the large polymerase (L) protein (fragment 1234 to 1900 AA). Antibodies to these proteins, in addition to anti-F antibodi

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC4379563 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature