The observation of evolutionary interaction pattern pairs in membrane proteins.

ABSTRACT:

Background

Over the last two decades, many approaches have been developed in bioinformatics that aim at one of the most promising, yet unsolved problems in modern life sciences--prediction of structural features of a protein. Such tasks addressed to transmembrane protein structures provide valuable knowledge about their three-dimensional structure. For this reason, the analysis of membrane proteins is essential in genomic and proteomic-wide investigations. Thus, many in-silico approaches have been utilized extensively to gain crucial advances in understanding membrane protein structures and functions.

Results

It turned out that amino acid covariation within interacting sequence parts, extracted from a evolutionary sequence record of α-helical membrane proteins, can be used f

SUBMITTER: Grunert S 

PROVIDER: S-EPMC4379700 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature