Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as peripheral blood is associated with T2D risk remains an open question. Age-related alteration of DNA methylation level was reported in certain methylation sites, but no association with T2D has been shown. Here we report on a population-based study of 929 men and women representing the East Jerusalem Palestinian (EJP) Arab population and compare with the findings among Israeli Ashkenazi Jews. This is the first reported epigenetic study of an Arab population with a cha

SUBMITTER: Toperoff G 

PROVIDER: S-EPMC4379765 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature