Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE.

ABSTRACT:

Objectives

The interferon (IFN) signature (IS) in patients with systemic lupus erythematosus (SLE) includes over 100 genes induced by type I IFN pathway activation. We developed a method to quantify the IS using three genes-the IS metric (ISM)-and characterised the clinical characteristics of patients with SLE with different ISM status from multiple clinical trials.

Methods

Blood microarray expression data from a training cohort of patients with SLE confirmed the presence of the IS and identified surrogate genes. We assayed these genes in a quantitative PCR (qPCR) assay, yielding an ISM from the IS. The association of ISM status with clinical disease characteristics was assessed in patients with extrarenal lupus and lupus nephritis from four clinical trials.

Results

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SUBMITTER: Kennedy WP 

PROVIDER: S-EPMC4379884 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature