Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation.

ABSTRACT: Several studies have recently identified strong epigenetic signals related to tobacco smoking. However, an aspect that did not receive much attention is the evolution of epigenetic changes with time since smoking cessation. We conducted a series of epigenome-wide association studies to capture the dynamics of smoking-induced epigenetic changes after smoking cessation, using genome-wide methylation profiles obtained from blood samples in 745 women from 2 European populations. Two distinct classes of CpG sites were identified: sites whose methylation reverts to levels typical of never smokers within decades after smoking cessation, and sites remaining differentially methylated, even more than 35 years after smoking cessation. Our results suggest that the dynamics of methylation changes follo

SUBMITTER: Guida F 

PROVIDER: S-EPMC4380075 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature