SHBG gene polymorphism (rs1799941) associates with metabolic syndrome in children and adolescents.

ABSTRACT:

Background

Metabolic syndrome (MetS) is a complex disorder characterized by coexistence of several cardiometabolic (CM) factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD). The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.

Methods

Genetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs), previously shown to modulate lipid or sex hormone binding globulin (SHBG) levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls).

Results

SUBMITTER: White MJ 

PROVIDER: S-EPMC4380117 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature