Systems biology of myasthenia gravis, integration of aberrant lncRNA and mRNA expression changes.

ABSTRACT:

Background

A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported in a number of complex human diseases, such as autoimmune diseases, neurological disorders, and various cancers. However, the aberrant lncRNAs implicated in myasthenia gravis (MG) remain unknown. The aim of the present study was to explore the abnormal expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) and examine mRNA regulatory relationship networks among MG patients with or without thymoma.

Methods

Microarray assays were performed, and the outstanding differences between lncRNAs or mRNA expression were verified through RT-PCR. The lncRNAs functions were ann

SUBMITTER: Luo Z 

PROVIDER: S-EPMC4380247 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature