Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.

ABSTRACT:

Purpose

Controversy exists regarding the use of continuous antibiotic prophylaxis vs observation in the management of children with vesicoureteral reflux. The reported effectiveness of continuous antibiotic prophylaxis in children with reflux varies widely. We determined whether the aggregated evidence supports use of continuous antibiotic prophylaxis in children with vesicoureteral reflux.

Materials and methods

We searched the Cochrane Controlled Trials Register, clinicaltrials.gov, MEDLINE(®), EMBASE(®), Google Scholar and recently presented meeting abstracts for reports in any language. Bibliographies of included studies were then hand searched for any missed articles. The study protocol was prospectively registered at PROSPERO (No. CRD42014009639). Reports were assessed

SUBMITTER: Wang HH 

PROVIDER: S-EPMC4380260 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature