Genome-wide interaction study identifies RCBTB1 as a modifier for smoking effect on carotid intima-media thickness.

ABSTRACT:

Objective

Carotid intima-media thickness (cIMT), a marker for atherosclerosis, is affected by smoking and has substantial interindividual variation. We sought to identify the genetic moderators influencing the effect of smoking on cIMT.

Approach and results

With a multistage design using 722 379 single nucleotide polymorphisms (SNP), a genome-wide interaction study was performed in a discovery sample of 669 Hispanics, followed by replication in 589 subjects (264 Hispanics, 172 non-Hispanic blacks, 153 non-Hispanic whites). Assuming an additive genetic model, regression analysis was performed to test for smoking-SNP interaction on cIMT while controlling for age, sex, and the top 3 principal components of ancestry. The strongest interaction in Hispanics was found with a synony

SUBMITTER: Wang L 

PROVIDER: S-EPMC4380266 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature