A modified collagen gel dressing promotes angiogenesis in a preclinical swine model of chronic ischemic wounds.

ABSTRACT: We recently performed proteomic characterization of a modified collagen gel (MCG) dressing and reported promising effects of the gel in healing full-thickness excisional wounds. In this work, we test the translational relevance of our aforesaid findings by testing the dressing in a swine model of chronic ischemic wounds recently reported by our laboratory. Full-thickness excisional wounds were established in the center of bipedicle ischemic skin flaps on the backs of animals. Ischemia was verified by laser Doppler imaging, and MCG was applied to the test group of wounds. Seven days post wounding, macrophage recruitment to the wound was significantly higher in MCG-treated ischemic wounds. In vitro, MCG up-regulated expression of Mrc-1 (a reparative M2 macrophage marker) and induced the expr

SUBMITTER: Elgharably H 

PROVIDER: S-EPMC4380279 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature