Age of collagen in intracranial saccular aneurysms.

ABSTRACT:

Background and purpose

The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries to investigate this further.

Methods

Forty-six ruptured and unruptured CA samples from 43 patients and 10 cadaveric human cerebral arteries were obtained. The age of collagen, extracted and purified from excised CAs, was estimated using (14)C birth dating and correlated with CA and patient characteristics, including the history of risk factors associated with atherosclerosis and potentially aneurysm growth and rupture.

Results

Nearly all CA samples conta

SUBMITTER: Etminan N 

PROVIDER: S-EPMC4380291 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature