MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model.

ABSTRACT:

Objective

To establish a miRNA signature for metastasis in an animal model of esophageal adenocarcinoma (EAC).

Background

The incidence of esophageal adenocarcinoma (EAC) has dramatically increased and esophageal cancer is now the sixth leading cause of cancer deaths worldwide. Mortality rates remain high among patients with advanced stage disease and esophagectomy is associated with high complication rates. Hence, early identification of potentially metastatic disease would better guide treatment strategies.

Methods

The modified Levrat's surgery was performed to induce EAC in Sprague-Dawley rats. Primary EAC and distant metastatic sites were confirmed via histology and immunofluorescence. miRNA profiling was performed on primary tumors with or without metastasis. A u

SUBMITTER: Zaidi AH 

PROVIDER: S-EPMC4380408 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature