Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.

ABSTRACT:

Background

Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.

Methods and findings

A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values

SUBMITTER: Mocroft A 

PROVIDER: S-EPMC4380415 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature