Safety of primed repetitive transcranial magnetic stimulation and modified constraint-induced movement therapy in a randomized controlled trial in pediatric hemiparesis.

ABSTRACT:

Objective

To investigate the safety of combining a 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) intervention in the contralesional hemisphere with a modified constraint-induced movement therapy (mCIMT) program in children with congenital hemiparesis.

Design

Phase 1 randomized, double-blinded, placebo-controlled pretest/posttest trial.

Setting

University academic facility and pediatric specialty hospital.

Participants

Subjects (N = 19; age range, 8-17 y) with congenital hemiparesis caused by ischemic stroke or periventricular leukomalacia. No subject withdrew because of adverse events. All subjects included completed the study.

Interventions

Subjects were randomized to 1 of 2 groups: either real rTMS plus mCIMT (n = 10) or

SUBMITTER: Gillick BT 

PROVIDER: S-EPMC4380609 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature