Excess body mass index- and waist circumference-years and incident cardiovascular disease: the CARDIA study.

ABSTRACT:

Objective

To determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD).

Methods

Prospective study of 4,061 white and black adults without CVD at baseline in 1985-1986 (age 18-30 years) from the multicenter, community-based CARDIA study. Time-varying excess body mass index (BMI)- and waist circumference (WC)-years were calculated as products of the degree and duration of excess overall (BMI ≥ 25 kg/m(2)) and abdominal adiposity [WC >94 cm (men) and >80 cm (women)], respectively, collected at up to eight examinations.

Results

During a median of 24.8 years, there were 125 incident CVD, 62 coronary heart disease (CHD), and 33 heart failure (HF) events. Adjusted hazard ratios for CVD,

SUBMITTER: Reis JP 

PROVIDER: S-EPMC4380633 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature