HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.

ABSTRACT:

Background

Subsets of high grade endometrial cancer (EnCa) over-express HER2 (ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing trastuzumab, an approved platform for HER2 positive breast cancer (BrCa). A truncated p95HER2 variant lacking the trastuzumab binding site may confer resistance. The objective of this investigation was to characterize the expression of the p95HER2 truncated variant in EnCa.

Materials and methods

With institutional approval, 86 high grade EnCa tumors were identified with tumor specimens from surgeries performed between 2000 and 2011. Clinical data were collected and all specimens underwent tumor genotyping, HER2 immunohistochemistry (IHC, HercepTest®), HER2 fluorescent in situ hybridization (FISH), along with to

SUBMITTER: Growdon WB 

PROVIDER: S-EPMC4380649 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature