Endoscopic and histologic findings in a cohort of uric acid and calcium oxalate stone formers.

ABSTRACT:

Objective

To characterize the endoscopic and histologic renal papillary lesions in a cohort of uric acid (UA) stone formers (SF).

Methods

Data were prospectively obtained during percutaneous nephrolithotomy between 2009 and 2013. Renal papillae were endoscopically analyzed to quantitate surface area occupied by plaque or plug, and biopsies were obtained. UA SF were compared with non-SF controls and patients with >50% calcium oxalate (CaOx) in the absence of UA.

Results

There were 23 UA SF; of which 19 stones (83%) were admixed with CaOx and 4 (17%) were pure. Compared with CaOx SF and controls, UA SF had a higher prevalence of diabetes and obesity, greater serum creatinine and UA levels, lower estimated glomerular filtration rate and urine pH, and elevated UA supersat

SUBMITTER: Viers BR 

PROVIDER: S-EPMC4380657 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature