Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium.

ABSTRACT:

Rationale

The mechanism of functional restoration by stem cell therapy remains poorly understood. Novel manganese-enhanced MRI and bioluminescence reporter gene imaging were applied to follow myocardial viability and cell engraftment, respectively. Human-placenta-derived amniotic mesenchymal stem cells (AMCs) demonstrate unique immunoregulatory and precardiac properties. In this study, the restorative effects of 3 AMC-derived subpopulations were examined in a murine myocardial injury model: (1) unselected AMCs, (2) ckit(+)AMCs, and (3) AMC-derived induced pluripotent stem cells (MiPSCs).

Objective

To determine the differential restorative effects of the AMC-derived subpopulations in the murine myocardial injury model using multimodality imaging.

Methods and results

SC

SUBMITTER: Kim PJ 

PROVIDER: S-EPMC4380765 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature