Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment.

ABSTRACT: Alzheimer's disease (AD) is a devastating disorder that strikes 1 in 10 Americans over the age of 65, and almost half of all Americans over 85 years old. The odds of an individual developing AD double every five years after the age of 65. While it has become increasingly common to meet heart attack or cancer survivors, there are no AD survivors. There is mounting evidence that dietary polyphenols, including resveratrol, may beneficially influence AD. Based on this consideration, several studies reported in the last few years were designed to validate sensitive and reliable translational tools to mechanistically characterize brain bioavailable polyphenols as disease-modifying agents to help prevent the onset of AD dementia and other neurodegenerative disorders. Several research groups world

SUBMITTER: Pasinetti GM 

PROVIDER: S-EPMC4380832 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature