Artificial metalloenzymes derived from three-helix bundles.

ABSTRACT: Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.

SUBMITTER: Tebo AG 

PROVIDER: S-EPMC4380837 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature