Construction of phosphorylation interaction networks by text mining of full-length articles using the eFIP system.

ABSTRACT: Protein phosphorylation is a reversible post-translational modification where a protein kinase adds a phosphate group to a protein, potentially regulating its function, localization and/or activity. Phosphorylation can affect protein-protein interactions (PPIs), abolishing interaction with previous binding partners or enabling new interactions. Extracting phosphorylation information coupled with PPI information from the scientific literature will facilitate the creation of phosphorylation interaction networks of kinases, substrates and interacting partners, toward knowledge discovery of functional outcomes of protein phosphorylation. Increasingly, PPI databases are interested in capturing the phosphorylation state of interacting partners. We have previously developed the eFIP (Extracting F

SUBMITTER: Tudor CO 

PROVIDER: S-EPMC4381107 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature