Hepatitis C virus reinfection after liver transplant: New chances and new challenges in the era of direct-acting antiviral agents.

ABSTRACT: The first interferon-free regimens have been approved for the treatment of patients with chronic hepatitis C virus (HCV). In the liver transplant (LT) setting, these regimens are expected to have an important effect, because graft loss due to HCV recurrence is a serious problem after LT. The response to the hitherto conventional treatment with pegylated interferon and ribavirin is poor. The significantly better response rates achieved with boceprevir-based and telaprevir-based triple therapy have led to better graft and patient survival rates, but severe drug interactions with immunosuppressants limit the feasibility of this therapy for LT patients. With the approval of sofosbuvir in January 2014, of simeprevir in May 2014, and of daclatasvir in August 2014, three antiviral agents are now

SUBMITTER: Herzer K 

PROVIDER: S-EPMC4381175 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature