Mapping the gating and permeation pathways in the voltage-gated proton channel Hv1.

ABSTRACT: Voltage-gated proton channels (Hv1) are ubiquitous throughout nature and are implicated in numerous physiological processes. The gene encoding for Hv1, however, was only identified in 2006. The lack of sufficient structural information of this channel has hampered the understanding of the molecular mechanism of channel activation and proton permeation. This study uses both simulation and experimental approaches to further develop existing models of the Hv1 channel. Our study provides insights into features of channel gating and proton permeation pathway. We compare open- and closed-state structures developed previously with a recent crystal structure that traps the channel in a presumably closed state. Insights into gating pathways were provided using a combination of all-atom molecular dy

SUBMITTER: Chamberlin A 

PROVIDER: S-EPMC4381436 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature