Effect of cool vs. warm dialysate on toxin removal: rationale and study design.

ABSTRACT:

Background

Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-compartmental resistance is the main barrier for toxin removal. Cool dialysate can potentially increase this resistance by vasoconstriction and thus impair the toxin removal. The aim of this trial is to compare the toxin removal outcome associated with cool vs. warm dialysate.

Method/design

This study is based on the hypothesis that dialysate temperature, a potential maneuver to maintain hemodynamic stability during HD, may influence inter-compartmental resistance and hence, toxin removal. Only stable HD patients will be recruited for this study. The quantum

SUBMITTER: Maheshwari V 

PROVIDER: S-EPMC4381674 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature