Ontology highlight
ABSTRACT:
SUBMITTER: Arichi N
PROVIDER: S-EPMC4381710 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Arichi Naoko N Mitsui Yozo Y Hiraki Miho M Nakamura Sigenobu S Hiraoka Takeo T Sumura Masahiro M Hirata Hiroshi H Tanaka Yuichiro Y Dahiya Rajvir R Yasumoto Hiroaki H Shiina Hiroaki H
Oncoscience 20150302 2
In the current study, we investigated a combination of docetaxel and thalidomide (DT therapy) in castration-resistant prostate cancer (CRPC) patients. We identified marker genes that predict the effect of DT therapy. Using an androgen-insensitive PC3 cell line, we established a docetaxel-resistant PC-3 cell line (DR-PC3). In DR-PC3 cells, DT therapy stronger inhibited proliferation/viability than docetaxel alone. Based on gene ontology analysis, we found versican as a selective gene. This result ...[more]