Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans.

ABSTRACT:

Background

Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations.

Objective

We investigated whether certain environmental and genetic factors are predictors of circulating 25(OH)D in 989 elderly African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study.

Methods

Regression analysis estimated the cross-sectional association of nongenetic (environmental) factors with 25(OH)D. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D in Caucasian genome-wide association studies (GWASs) were analyzed for association with serum 25(OH)D, including analyses of all imputed SNPs in identified genomic regions. Genome-wide compl

SUBMITTER: Hansen JG 

PROVIDER: S-EPMC4381765 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature