Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats.

ABSTRACT:

Objective

Progesterone (P₄) plays a central role in women's health. Synthetic progestins are used clinically in hormone replacement therapy (HRT), oral contraceptives, and for the treatment of endometriosis and infertility. Unfortunately, synthetic progestins are associated with side effects, including cardiovascular disease and breast cancer. Botanical dietary supplements are widely consumed for the alleviation of a variety of gynecological issues, but very few studies have characterized natural compounds in terms of their ability to bind to and activate progesterone receptors (PR). Kaempferol is a flavonoid that functions as a non-steroidal selective progesterone receptor modulator (SPRM) in vitro. This study investigated the molecular and physiological effects

SUBMITTER: Toh MF 

PROVIDER: S-EPMC4382015 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature