Ih channels control feedback regulation from amacrine cells to photoreceptors.

ABSTRACT: In both vertebrates and invertebrates, photoreceptors' output is regulated by feedback signals from interneurons that contribute to several important visual functions. Although synaptic feedback regulation of photoreceptors is known to occur in Drosophila, many questions about the underlying molecular mechanisms and physiological implementation remain unclear. Here, we systematically investigated these questions using a broad range of experimental methods. We isolated two Ih mutant fly lines that exhibit rhythmic photoreceptor depolarization without light stimulation. We discovered that Ih channels regulate glutamate release from amacrine cells by modulating calcium channel activity. Moreover, we showed that the eye-enriched kainate receptor (EKAR) is expressed in photoreceptors and receiv

SUBMITTER: Hu W 

PROVIDER: S-EPMC4382183 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature