Robust differences in antisaccade performance exist between COGS schizophrenia cases and controls regardless of recruitment strategies.

ABSTRACT: The impaired ability to make correct antisaccades (i.e., antisaccade performance) is well documented among schizophrenia subjects, and researchers have successfully demonstrated that antisaccade performance is a valid schizophrenia endophenotype that is useful for genetic studies. However, it is unclear how the ascertainment biases that unavoidably result from recruitment differences in schizophrenia subjects identified in family versus case-control studies may influence patient-control differences in antisaccade performance. To assess the impact of ascertainment bias, researchers from the Consortium on the Genetics of Schizophrenia (COGS) compared antisaccade performance and antisaccade metrics (latency and gain) in schizophrenia and control subjects from COGS-1, a family-based schizophre

SUBMITTER: Radant AD 

PROVIDER: S-EPMC4382408 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature