Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.

ABSTRACT:

Background

Genome-wide association studies have established ADAMTS7 as a locus for coronary artery disease in humans. However, these studies fail to provide directionality for the association between ADAMTS7 and coronary artery disease. Previous reports have implicated ADAMTS7 in the regulation of vascular smooth muscle cell migration, but a role for and the direction of impact of this gene in atherogenesis have not been shown in relevant model systems.

Methods and results

We bred an Adamts7 whole-body knockout mouse onto both the Ldlr and Apoe knockout hyperlipidemic mouse models. Adamts7(-/-)/Ldlr(-/-) and Adamts7(-/-)/Apoe(-/-) mice displayed significant reductions in lesion formation in aortas and aortic roots compared with controls. Adamts7 knockout mice also showed red

SUBMITTER: Bauer RC 

PROVIDER: S-EPMC4382454 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature