Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.

ABSTRACT:

Importance

Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer.

Objective

To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and/or NSAIDs and single-nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Design, setting, and participants

Case-control study using data from 5 case-control and 5 cohort studies initiated between 1976 and 2003 across the United States, Canada, Australia, and Germany and including colorectal cancer cases (n=8634) and matched controls (n=8553) ascertained between 1976 and 2011. Participants were all of European descent.

SUBMITTER: Nan H 

PROVIDER: S-EPMC4382867 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature