Ontology highlight
ABSTRACT:
SUBMITTER: Kovac M
PROVIDER: S-EPMC4383019 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature communications 20150319
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes of 31 pRCCs, and in four tumours, multi-region sequencing is undertaken. We identify BAP1, SETD2, ARID2 and Nrf2 pathway genes (KEAP1, NHE2L2 and CUL3) as probable drivers, together with at least eight other possible drivers. However, only ~10% of tumours harbour detectable pathogenic changes i ...[more]