Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture.

ABSTRACT: The unique properties provided by hybrid semiconductor quantum dot (QD) bioconjugates continue to stimulate interest for many applications ranging from biosensing to energy harvesting. Understanding both the structure and function of these composite materials is an important component in their development. Here, we compare the architecture that results from using two common self-assembly chemistries to attach DNA to QDs. DNA modified to display either a terminal biotin or an oligohistidine peptidyl sequence was assembled to streptavidin/amphiphilic polymer- or PEG-functionalized QDs, respectively. A series of complementary acceptor dye-labeled DNA were hybridized to different positions on the DNA in each QD configuration and the separation distances between the QD donor and each dye-accept

SUBMITTER: Boeneman K 

PROVIDER: S-EPMC4383186 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature