Ontology highlight
ABSTRACT:
SUBMITTER: Ford CB
PROVIDER: S-EPMC4383195 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
eLife 20150203
Candida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromised individuals. Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance. Studies in clinical isolates have implicated multiple mechanisms in resistance, but have focused on large-scale aberrations or candidate genes, and do not comprehensively chart the genetic basis of adaptation. Here, we leveraged next-generation sequencing to anal ...[more]