Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.

ABSTRACT:

Background

PTEN loss contributes to the development of liver diseases including hepatic steatosis and both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). The factors that influence the penetrance of these conditions are unclear. We explored the influence of sustained hypoxia signaling through co-deletion of Pten and Vhl in a murine model.

Methods

We used a CreER-linked Keratin 18 mouse model to conditionally delete Pten, Vhl or both in somatic cells of adult mice, evaluating the resultant tumors by histology and gene expression microarray. Existing sets of gene expression data for human HCC and CC were examined for pathways related to those observed in the murine tumors, and a cohort of human CC samples was evaluated for relati

SUBMITTER: Sendor AB 

PROVIDER: S-EPMC4383253 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature