Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.

ABSTRACT: Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4383254 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature