Ontology highlight
ABSTRACT:
SUBMITTER: Vliet-Gregg PA
PROVIDER: S-EPMC4383269 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Vliet-Gregg Portia A PA Hamilton Jennifer R JR Katzenellenbogen Rachel A RA
Virology 20150225
High-risk human papillomavirus (HR HPV) oncoproteins bind host cell proteins to dysregulate and uncouple apoptosis, senescence, differentiation, and growth. These pathways are important for both the viral life cycle and cancer development. HR HPV16 E6 (16E6) interacts with the cellular protein NFX1-123, and they collaboratively increase the growth and differentiation master regulator, Notch1. In 16E6 expressing keratinocytes (16E6 HFKs), the Notch canonical pathway genes Hes1 and Hes5 were incre ...[more]