Impact of parturition on chemokine homing factor expression in the vaginal distention model of stress urinary incontinence.

ABSTRACT:

Purpose

Human childbirth simulated by vaginal distention is known to increase the expression of chemokines and receptors involved in stem cell homing and tissue repair. We hypothesized that pregnancy and parturition in rats contributes to the expression of chemokines and receptors after vaginal distention.

Materials and methods

We used 72 age matched female Lewis rats, including virgin rats with and without vaginal distention, and delivered rats with and without vaginal distention. Each rat was sacrificed immediately, or 3 or 7 days after vaginal distention and/or parturition, and the urethra was harvested. Relative expression of chemokines and receptors was determined by real-time polymerase chain reaction. Mixed models were used with the Bonferroni correction for multiple

SUBMITTER: Lenis AT 

PROVIDER: S-EPMC4383296 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature